Animal Models in Toxicologic Research: Pig 

This chapter in the pivotal collection, Haschek and Rousseaux's Handbook of Toxicologic Pathology, reviews the utility of pigs as translational models in toxicologic research. It provides a comprehensive overview of porcine anatomy, physiology, and background pathology. Furthermore, it evaluates their distinct translational characteristics and explores their expanding role in regulatory safety-assessment programs. This work serves as an essential reference for validating the predictive value of porcine models in drug development and chemical safety.

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Citation:
Helke, K., Nelson, K., & Sargeant, A. (2022). Animal models in toxicologic research: Pig. In W. M. Haschek, C. G. Rousseaux, M. A. Wallig, & B. Bolon (Eds.), Haschek and Rousseaux’s handbook of toxicologic pathology (4th ed., pp. 751–776). Academic Press. https://doi.org/10.1016/B978-0-12-821044-4.00001-7