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title: Publication - Introducing the Sinclair Nanopig
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###### External Publication

#### **Introducing the Sinclair Nanopig™ Model: Preliminary Genomic, Proteomic, and Hepatic CYP450 Characterization for (Bio)Pharmaceutical Safety Assessment**

This publication presents genomic, tissue-proteomic, and hepatic cytochrome P450 characterization of the Sinclair Nanopig™. The findings identify human-orthologous drug-metabolizing enzymes, transporters, and immune-related proteins and support evaluation of the model for pharmacology and safety-assessment programs.

##### [Access the publication on ScienceDirect](https://www.sciencedirect.com/science/article/abs/pii/S1056871925008147)

Citation:   
Chen, Y., Bivens, N., An, H., Mooney, B., Nguyen, T., Coghill, L., Horkman, J., Haupt, L., Evans, M., Campbell, R., & Davis, W. (2025). Introducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment. *Journal of Pharmacological and Toxicological Methods, 136*, 108394. [https://doi.org/10.1016/j.vascn.2025.108394](https://doi.org/10.1016/j.vascn.2025.108394)  

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