Introducing the Sinclair Nanopig™ Model: Preliminary Genomic, Proteomic, and Hepatic CYP450 Characterization for (Bio)Pharmaceutical Safety Assessment

This publication presents genomic, tissue-proteomic, and hepatic cytochrome P450 characterization of the Sinclair Nanopig™. The findings identify human-orthologous drug-metabolizing enzymes, transporters, and immune-related proteins and support evaluation of the model for pharmacology and safety-assessment programs.

Access the publication on ScienceDirect

Citation:
Chen, Y., Bivens, N., An, H., Mooney, B., Nguyen, T., Coghill, L., Horkman, J., Haupt, L., Evans, M., Campbell, R., & Davis, W. (2025). Introducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment. Journal of Pharmacological and Toxicological Methods, 136, 108394. https://doi.org/10.1016/j.vascn.2025.108394